Prague Castle
Prague Castle is the obvious first landmark because it gives you history, scale, views, and a route through several versions of the city at once. Treat it as a district rather than a single stop: the courtyards, cathedral, palace interiors, gardens, and lanes all reward a slower visit, especially if you arrive early or later in the afternoon.
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Old Town Hall and Astronomical Clock
Old Town Hall is the central Prague classic: the Astronomical Clock outside, historic rooms inside, and one of the most useful tower views over Old Town Square. It works well near the start of a trip because it helps you understand the shape of the old centre before you start wandering side streets.
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Jewish Museum Prague
The Jewish Museum is not one building but a set of Josefov sites, including synagogues, exhibitions, and the Old Jewish Cemetery. It is one of Prague's most important cultural visits, best approached with enough time and attention for the history rather than squeezed between quick photo stops.
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Lobkowicz Palace
Lobkowicz Palace sits inside the Prague Castle complex but feels more personal than the large state spaces around it. Go for the private collection, the music history, the paintings, and the terrace views; it is a good choice if you want an art-and-history stop that still fits naturally into a Castle day.
Strahov Library and Strahov Monastery
Strahov Library is for ornate interiors, monastery atmosphere, rare books, and the walk above the city. The Theological and Philosophical halls are the draw, but the location matters too: pair it with Petrin, Loreto, or a downhill walk toward Prague Castle and Lesser Town.